Understanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content
نویسندگان
چکیده
منابع مشابه
Herbal Pharmacokinetics: A Practitioner Update With Reference to St. John’s Wort (Hypericum perforatum) Herb-Drug Interactions
Why Pharmacokinetics? Herbalists have long studied the effect of herbal medicines on the body, but have hitherto paid less attention to the effects of the body on herbal medicines. This dichotomy expresses the distinction in classical pharmacology between pharmacodynamics and pharmacokinetics. For a given dose of any herbal medicine, its physiological effect (or that of its constituents) will b...
متن کاملPharmacokinetic interactions of Hypericum perforatum L. (St John's wort) with conventional drugs: a review of clinical studies
Background and objectives: Hypericum perforatum L., commonly known as St. John’s wort (SJW) from the family Hypericaceae is a famous medicinal plant used to treat mild to moderate depression; so, it might affect the pharmacokinetics of numerous drugs. Due to widespread herb-drug interactions of SJW, this study was designed to review the clinical evidences regarding the...
متن کاملSt. John's wort (Hypericum perforatum) and warfarin: Dangerous liaisons!
An 85-year-old male patient with a history of hypertension, old anterior wall myocardial infarction and atrial fibrillation was placed on warfarin one year previously. However, he did not comply with regular international normalized ratio (INR) measurements, but kept taking warfarin (5 mg) on a daily basis for almost a year without any problems. After watching a television program about herbal ...
متن کاملSt John’s wort (Hypericum perforatum)-induced psychosis: a case report
BACKGROUND St John's wort (Hypericum perforatum) has been known for centuries for its therapeutic properties and its efficacy as an antidepressant has been confirmed by a growing body of evidence. During the last two decades it has also come to prominence with a wider public, due to advertising efforts across Europe and United States of America. However, its availability without prescription, a...
متن کاملSt John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties.
The chemical composition of St. John's wort has been well-studied. Documented pharmacological activities, including antidepressant, antiviral, and antibacterial effects, provide supporting evidence for several of the traditional uses stated for St John's wort. Many pharmacological activities appear to be attributable to hypericin and to the flavonoid constituents; hypericin is also reported to ...
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ژورنال
عنوان ژورنال: Journal of Pharmacy and Pharmacology
سال: 2018
ISSN: 2042-7158,0022-3573
DOI: 10.1111/jphp.12858